SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM THESIS

Fatty acids liberated from the lipid digestion process interact with the bile salts and result in the formation of mixed micelles and micelles in which the drug gets solubilized. SMEDDS can improve oral bioavailability by enhancing permeation across the intestinal membrane, solubilization, a reduced or eliminated effect of food, droplet size reduction, lymphatic transport, and improvement of drug dissolution. Typical ternary diagram indicating the composition of A, B, and C at point O. This enhanced lymph delivery of the drug can bypass the first pass extraction whereby the bioavailability of drugs that undergo extensive first pass effect can be improved. At regular intervals the samples should be collected and tested for appearance, color, drug content, pH of diluted formulation, and dissolution profile. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Then pseudoternary diagram should be plotted with the help of suitable software.

The less toxicity offered by nonionic surfactants like oleates, polysorbates, polyoxyls, and so forth compared to ionic surfactants allows them to be used more commonly in the formulation of SMEDDS [ 29 ]. Salt formation is not achievable with neutral drug molecules and the performance of salt forms in the GIT may not be efficacious because they will not exist in the original form; instead they get converted into acid or base by which the approach may not be useful. The free energy of the emulsion can be described by the following equation: The peaks give information about the condition of water like bound state or free state [ 55 ]. Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: Optimal drug incorporation can be achieved if good compatibility exists between the added drug and the system with respect to physical and chemical properties.

The greater bioavailability from the SMEDDS can be achieved when the dose is very low especially for the drugs with high octanol: Most of the hydrophobic drugs have good solubility in synthetic oils and surfactants compared to that in oils from natural source [ 22 ].

Alcoholic, low molecular weight cosolvents may cause precipitation of the drug when the formulation is filled in gelatin capsules since they are absorbed onto the capsule shells [ 24 ]. Refractive index is mainly dependent on two factors, that is, amount of the cosurfactant and globule size. Although many formulation approaches like solid dispersions, complexation, pH modification, and microemulsiying exist, lipid based delivery systems finding increased appliance with the apparent increase in absorption of drug.

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At different compositions, different structures may be formed like emulsions, microemulsions, micelles, inverted micellar forms, and so forth and the extent of formation of these structures can be known with the construction of phase diagram.

[Full text] Self-microemulsifying drug-delivery system for improved oral bioavaila | IJN

Constant plasma levels of drug might be due to presentation of the poorly soluble drug in dissolved form that bypasses the critical step in drug absorption, that is, dissolution [ 13 ].

If the drug is highly lipophilic and does not have the ability to form H-bonds, there will not be any effect of drug addition even in high concentrations. Although microekulsifying oils based on natural origin are favored, they are not useful as they do not have sufficient capacity to solubilize large amount of lipophilic drug and self-emulsification is also problematic with them as they possess thssis large molecular volume [ 21 ]. University of Mumbai, India; Microejulsifying inhibitory effect of surfactants on p-glycoprotein helps in the improvement of overall bioavailability of many drugs that are substrates to p-glycoprotein transporter [ 13 ].

Gershanik T, Benita S. Among various lipid based formulations liposomes, solid lipid nanoparticles, self-dispersing tablets, and solid solutionsself-microemulsifying formulations are receiving more attention by formulation scientists as these are advantageous in the aspect of their stability, self-dispersing thfsis, ease of preparation, and scale-up.

self microemulsifying drug delivery system thesis

Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: The efficiency of nanoemulsion formation was assessed by adding mg of each mixture to 40 mL of double distilled water, followed by gentle agitation using a magnetic theeis.

Spectroscopic techniques like photon correlation spectroscopy and microscopic techniques are used for droplet size analysis [ 330 ]. The emulsification ability of surfactants can be known by mixing the equal proportions of selected oil and surfactant which is followed by homogenization.

At high concentrations of surfactant, GI irritation occurs due to tissue damage [ 35 ] and the efficiency of self-emulsification capacity decreases which may be due to the formation of liquid crystalline phase at the interface which in turn is due to viscous nature [ 33 ].

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Cosolvent Cosolvents facilitate the dissolution of surfactant and hydrophobic drug in oil phase because of their ability to access the entry of water into the formulation. The solvents of 5 mM ammonium acetic acid pH 7. As microemulsions are thermodynamically stable, equilibrium exists within the system although there is continuous exchange of matter between the different phases.

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Phase separation and decrease in drug solubilization are commonly observed at microemulsivying temperature than the cloud point due to the susceptibility of surfactant to dehydration [ 42 microemulsifyjng.

self microemulsifying drug delivery system thesis

The nanoemulsions formed were visually observed for phase clarity, self-emulsification time, and rate of emulsification. Table 1 shows the main parameters of syystem mass spectrometry conditions used for all analytes.

Evaluation of liquid crystalline structures formed by the dilution of SMEDDS is important as these govern the stability of formulation, self-emulsification, and extent of drug release. Apart from poor water solubility, appreciable solubility of the drug in oil phase is important in the selection of suitable drug candidate for the formulation of lipid based delivery systems like SMEDDS [ 24 ].

The residence time of microemylsifying drug can be prolonged by this inhibition of efflux [ 8 ].

self microemulsifying drug delivery system thesis

However it is not always possible with all drug molecules. Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: You can learn about what data of yours we retain, how it is processed, who it is shared with systrm your right to have your data deleted by reading our Privacy Policy.

The selection of suitable surfactant and cosurfactant should be done by considering the efficacy, irritancy, change in efficacy caused by repeated administration of formulation, their interaction with the proteins and lipids of the mucosa, and metabolic pathway followed by them [ 22 ].

There was no change in mean particle size and self-emulsification time. Published 12 February Volume The droplet size is mainly dependent on the nature and concentration of surfactant [ 35 ]. Solubility of the drug in various oils, surfactants, and cosurfactants should be tested [ 3839 ]. The determination of polydispersity index PDI gives suitable information about size distribution.